Structure of PDB 7lhz Chain B Binding Site BS02

Receptor Information
>7lhz Chain B (length=631) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNT
WEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLH
IATLLCALFVRHFRTLVKEGHVYVALPPLYQRFKGLGEMNPMQLRETTLD
PNTRRLVQLVISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEKGSDMAERL
ALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASA
KFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGA
PDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLP
ARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLD
IVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVLPHQVSGAKVLEQI
AAQMRNEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLV
FRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPA
LMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILA
SERKMNNLLKKELQADADAFGDDRRSPLHER
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lhz Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		L446 N447 S459 H498 L502 R616 Y1018 A1117 I1172 A1173 G1175 M1176 S1324
Binding residue
(residue number reindexed from 1)		L48 N49 S61 H100 L104 R185 Y210 A309 I364 A365 G367 M368 S472
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7lhz, PDBe:7lhz, PDBj:7lhz
PDBsum7lhz
PubMed33929852
UniProtB5XU53;
B5XU60

[Back to BioLiP]