Structure of PDB 7kfa Chain B Binding Site BS02

Receptor Information

>7kfa Chain B (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SIPWNLERITPPRYRSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEED
ASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLE
FIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFR
DDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDII
GASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFS
AKDVINEAWFPEDQRVLTPNLVAALPPSQLFCRTVWSAHSGPTRMATAIA
RCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAGEGVYAIARCC
LLPQANCSVHTAPPTRVHCHQQGHVLTGCSSHWEVEDQPNQCVGHEASIH
ASCCHAPGLECKVKEHGIQEQVTVACEEGWTLTGCSALPGTSHVLGAYAV
DNTCVVRSRAVTAVAICCRSR

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7kfa Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7kfa Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Resolution	2.45 Å
Binding residue (original residue number in PDB)	V333 T335 C358
Binding residue (residue number reindexed from 1)	V164 T166 C189
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.21.-

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:7kfa, PDBe:7kfa, PDBj:7kfa
PDBsum	7kfa
PubMed	34547225
UniProt	Q8NBP7\|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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