Structure of PDB 7k5k Chain B Binding Site BS02

Receptor Information
>7k5k Chain B (length=545) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLNS
APKHSSSGGSGGNGGSAGSSGNGEGGAQIKINSSVKDNTINEFLKEGNME
NFTGKLGTSKSFYIANDQKKYVSLAYVGCGPANEETELEIRKVAYALVTL
LHDSKHKKVSIIFEIKIEEALFRFFLEHLFYEYVTDERFKSADKSTETDF
IKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNYCNPVSLSNA
AVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKFIHLTYKGAQ
TGASQNEKKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLG
CAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNT
DAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNDQ
LINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASSVVA
SLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7k5k Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7k5k Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		K390 D395 D415 E477
Binding residue
(residue number reindexed from 1)		K316 D321 D341 E403
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k5k, PDBe:7k5k, PDBj:7k5k
PDBsum7k5k
PubMed33303633
UniProtA5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)

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