Structure of PDB 7juq Chain B Binding Site BS02

Receptor Information

>7juq Chain B (length=277) Species: 9606 (Homo sapiens)

TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWGEVAIRLIDIERDNED
QLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR
DAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT
DFGLFSISGVLQREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHS
DVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISD
ILLFCWAFEQEERPTFTKLMDMLEKLP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7juq Chain B Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7juq Structural basis for the action of the drug trametinib at KSR-bound MEK.
• Resolution: 3.22 Å
• Binding residue (original residue number in PDB): N791 D803
• Binding residue (residue number reindexed from 1): N139 D151
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D786 K788 K790 N791 D803 Q825
• Catalytic site (residue number reindexed from 1): D134 K136 K138 N139 D151 Q170
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7juq, PDBe:7juq, PDBj:7juq
• PDBsum: 7juq
• PubMed: 32927473
• UniProt: Q6VAB6|KSR2_HUMAN Kinase suppressor of Ras 2 (Gene Name=KSR2)