Structure of PDB 7jl8 Chain B Binding Site BS02

Receptor Information
>7jl8 Chain B (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKVGDGQRIYLVTTYAEFW
FYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPANPGADGKKMVALLIEY
VCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLIFQLHDVAFKDNIHVGN
FLRKILQPALDLLDLSFLVVKNNMGEKHLFVDLGVYTRNRNFRLYKSSKI
GKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLVSNVRFSDTLRILTCEP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7jl8 Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D280 R288
Binding residue
(residue number reindexed from 1)		D182 R190
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jl8, PDBe:7jl8, PDBj:7jl8
PDBsum7jl8
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

[Back to BioLiP]