Structure of PDB 7h2r Chain B Binding Site BS02

Receptor Information
>7h2r Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDGWA
InChIInChI=1S/C11H14N2O3/c1-8(14)12-9-4-3-5-10(6-9)13-11(15)7-16-2/h3-6H,7H2,1-2H3,(H,12,14)(H,13,15)
InChIKeyZDALGCTWWSVNDR-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385COCC(=O)Nc1cccc(NC(C)=O)c1
OpenEye OEToolkits 2.0.6CC(=O)Nc1cccc(c1)NC(=O)COC
FormulaC11 H14 N2 O3
Name~{N}-(3-acetamidophenyl)-2-methoxy-ethanamide
ChEMBL
DrugBank
ZINCZINC000000860450
PDB chain7h2r Chain B Residue 205 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7h2r PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.321 Å
Binding residue
(original residue number in PDB)		Y130 A132 S135 G151 Y161
Binding residue
(residue number reindexed from 1)		Y115 A117 S120 G136 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h2r, PDBe:7h2r, PDBj:7h2r
PDBsum7h2r
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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