Structure of PDB 7h2p Chain B Binding Site BS02

Receptor Information
>7h2p Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDA1AKA
InChIInChI=1S/C7H11N3/c1-6-4-9-10-3-2-8-5-7(6)10/h4,8H,2-3,5H2,1H3
InChIKeyGHWWEPXDSAHILS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7Cc1cnn2c1CNCC2
ACDLabs 12.01
CACTVS 3.385		Cc1cnn2CCNCc12
FormulaC7 H11 N3
Name(8S)-3-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
ChEMBL
DrugBank
ZINC
PDB chain7h2p Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7h2p PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.452 Å
Binding residue
(original residue number in PDB)		D129 A132 Y150 Y161
Binding residue
(residue number reindexed from 1)		D114 A117 Y135 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h2p, PDBe:7h2p, PDBj:7h2p
PDBsum7h2p
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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