Structure of PDB 7h2a Chain B Binding Site BS02

Receptor Information
>7h2a Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDZ2Z
InChIInChI=1S/C10H9NO2S/c1-14(12,13)9-6-2-4-8-5-3-7-11-10(8)9/h2-7H,1H3
InChIKeyRPUNNHCLJDHINC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01CS(=O)(=O)c1cccc2cccnc12
OpenEye OEToolkits 2.0.7CS(=O)(=O)c1cccc2c1nccc2
CACTVS 3.385C[S](=O)(=O)c1cccc2cccnc12
FormulaC10 H9 N O2 S
Name8-(methanesulfonyl)quinoline
ChEMBL
DrugBank
ZINCZINC000039140297
PDB chain7h2a Chain B Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7h2a PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.709 Å
Binding residue
(original residue number in PDB)		K54 G55 P67 Y68
Binding residue
(residue number reindexed from 1)		K39 G40 P52 Y53
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h2a, PDBe:7h2a, PDBj:7h2a
PDBsum7h2a
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

[Back to BioLiP]