Structure of PDB 7g95 Chain B Binding Site BS02

Receptor Information
>7g95 Chain B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRT
LKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQ
ALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYK
ELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQ
HSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Ligand information
Ligand IDW0Y
InChIInChI=1S/C8H10N2O3S/c1-10-8(11)6-2-4-7(5-3-6)14(9,12)13/h2-5H,1H3,(H,10,11)(H2,9,12,13)
InChIKeyCTDFBRMMEMHBEO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CNC(=O)c1ccc(cc1)S(=O)(=O)N
ACDLabs 12.01NS(c1ccc(cc1)C(NC)=O)(=O)=O
CACTVS 3.385CNC(=O)c1ccc(cc1)[S](N)(=O)=O
FormulaC8 H10 N2 O3 S
NameN-methyl-4-sulfamoylbenzamide
ChEMBLCHEMBL67676
DrugBank
ZINCZINC000000403245
PDB chain7g95 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g95 ARHGEF2 PanDDA analysis group deposition
Resolution1.551 Å
Binding residue
(original residue number in PDB)		S327 G328 A331 E332 C335 L425
Binding residue
(residue number reindexed from 1)		S124 G125 A128 E129 C132 L222
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:7g95, PDBe:7g95, PDBj:7g95
PDBsum7g95
PubMed
UniProtQ92974|ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Gene Name=ARHGEF2)

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