Structure of PDB 7g8b Chain B Binding Site BS02

Receptor Information
>7g8b Chain B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRT
LKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQ
ALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYK
ELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQ
HSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Ligand information
Ligand IDLFO
InChIInChI=1S/C11H12N2O/c1-12-11(14)9-7-13(2)10-6-4-3-5-8(9)10/h3-7H,1-2H3,(H,12,14)
InChIKeyOHXYWSIWHXTWCT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CNC(=O)c1cn(c2c1cccc2)C
CACTVS 3.385CNC(=O)c1cn(C)c2ccccc12
ACDLabs 12.01CNC(=O)c1cn(C)c2ccccc21
FormulaC11 H12 N2 O
NameN,1-dimethyl-1H-indole-3-carboxamide
ChEMBL
DrugBank
ZINCZINC000004054174
PDB chain7g8b Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g8b ARHGEF2 PanDDA analysis group deposition
Resolution1.42 Å
Binding residue
(original residue number in PDB)		E332 C335 N428
Binding residue
(residue number reindexed from 1)		E129 C132 N225
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:7g8b, PDBe:7g8b, PDBj:7g8b
PDBsum7g8b
PubMed
UniProtQ92974|ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Gene Name=ARHGEF2)

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