Structure of PDB 7fjj Chain B Binding Site BS02

Receptor Information
>7fjj Chain B (length=1095) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPM
WYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRG
SQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVK
GVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGR
FYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGPSLEEC
QKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVP
VKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLL
FEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTG
NWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQ
PSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVED
VNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFV
SISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFE
DFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLI
PYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKT
KTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVY
KNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVE
NKQVLVNKSMPTQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQ
TRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSR
MTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKD
YVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTE
GRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLG
YSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7fjj Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Q183 K186 R195 K210 K211 S212 R213 N228 Q294 K430 M431 D432 R433 Q458 F459 K461 T462
Binding residue
(residue number reindexed from 1)		Q161 K164 R173 K188 K189 S190 R191 N206 Q272 K408 M409 D410 R411 Q436 F437 K439 T440
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042796 snRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7fjj, PDBe:7fjj, PDBj:7fjj
PDBsum7fjj
PubMed34675218
UniProtQ9NW08|RPC2_HUMAN DNA-directed RNA polymerase III subunit RPC2 (Gene Name=POLR3B)

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