Structure of PDB 7fji Chain B Binding Site BS02

Receptor Information
>7fji Chain B (length=1097) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTS
DADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDI
EYTRGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGG
YFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMA
VKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIGTEEHVMAAFGP
SLEECQKAQIFTQMQALKYIGNKVRRQKTKIEEARELLASTILTHVPVKE
FNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFED
LFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS
LKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQ
WGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNL
LCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSIS
TNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFL
HESLVEYLDVNEENDCNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYP
HHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTI
ELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNA
KCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQ
VLVNKSMPTVTQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLL
RQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFP
SRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLG
KDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQP
TEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGL
LGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7fji Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		G1038 R1039 R1046 G1048 E1049 M1050
Binding residue
(residue number reindexed from 1)		G1003 R1004 R1011 G1013 E1014 M1015
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042796 snRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fji, PDBe:7fji, PDBj:7fji
PDBsum7fji
PubMed34675218
UniProtQ9NW08|RPC2_HUMAN DNA-directed RNA polymerase III subunit RPC2 (Gene Name=POLR3B)

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