Structure of PDB 7fdw Chain B Binding Site BS02

Receptor Information

>7fdw Chain B (length=348) Species: 9913 (Bos taurus)

YTRVVWCAVGPEEQKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADA
LNLDGGYIYTAGKCGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKK
ANEGLTWNSLKDKKSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSC
APGADPKSRLCALCAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVA
FVKNDTVWENTNGESTADWAKNLNREDFRLLCLDGTRKPVTEAQSCHLAV
APNHAVVSRSDRAAHVKQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLF
NDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSTSPLLEACAFLTR

Ligand information

• Ligand ID: CO3
• InChI: InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
• InChIKey: BVKZGUZCCUSVTD-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: C(=O)([O-])[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-]C([O-])=O
• Formula: C O3
• Name: CARBONATE ION
• DrugBank: DB14531
• PDB chain: 7fdw Chain B Residue 704

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7fdw A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 angstrom Resolution.
• Resolution: 2.277 Å
• Binding residue (original residue number in PDB): D395 Y433 T459 R463 T464 A465 Y526 H595
• Binding residue (residue number reindexed from 1): D54 Y92 T118 R122 T123 A124 Y185 H254
• Annotation score: 3

Enzymatic activity

• Enzyme Commision number: 3.4.21.-

Gene Ontology

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:7fdw, PDBe:7fdw, PDBj:7fdw
• PDBsum: 7fdw
• PubMed: 34734372
• UniProt: P24627|TRFL_BOVIN Lactotransferrin (Gene Name=LTF)