Structure of PDB 7f7i Chain B Binding Site BS02
Receptor Information
>7f7i Chain B (length=191) Species:
10116
(Rattus norvegicus) [
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FQGPGSEFVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKRE
YEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQ
GKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARK
AFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSG
Ligand information
>7f7i Chain I (length=12) Species:
32630
(synthetic construct) [
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RIRRDEYLKAIQ
Receptor-Ligand Complex Structure
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PDB
7f7i
Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Resolution
2.595 Å
Binding residue
(original residue number in PDB)
S528 F530 V531 Y533 H642 H644 D710 L711 S712 G713
Binding residue
(residue number reindexed from 1)
S6 F8 V9 Y11 H120 H122 D188 L189 S190 G191
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7f7i
,
PDBe:7f7i
,
PDBj:7f7i
PDBsum
7f7i
PubMed
34458841
UniProt
P31016
|DLG4_RAT Disks large homolog 4 (Gene Name=Dlg4)
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