Structure of PDB 7ela Chain B Binding Site BS02

Receptor Information
>7ela Chain B (length=49) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGPQFCKSCWAENKGLVECNNHYLCLNCLTLLLGVSSRCPICKMPLPT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ela Chain B Residue 102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ela Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C44 H47
Binding residue
(residue number reindexed from 1)		C20 H23
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0039702 viral budding via host ESCRT complex
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0030430 host cell cytoplasm
GO:0044220 host cell perinuclear region of cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ela, PDBe:7ela, PDBj:7ela
PDBsum7ela
PubMed34127846
UniProtA0A097F4I8

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