Structure of PDB 7drj Chain B Binding Site BS02

Receptor Information

>7drj Chain B (length=186) Species: 158879 (Staphylococcus aureus subsp. aureus N315)

MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIF
ILASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTN
SVVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLL
GDPLATLIGLSLGQILLYIGVIFTILSGIEYFYKGR

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7drj Chain B Residue 711

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7drj The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): D57 D78 D82
• Binding residue (residue number reindexed from 1): D57 D78 D82
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.8.5: CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase.

Gene Ontology

Molecular Function

• GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
• GO:0016740 transferase activity
• GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Biological Process

• GO:0006655 phosphatidylglycerol biosynthetic process
• GO:0008654 phospholipid biosynthetic process
• GO:0046474 glycerophospholipid biosynthetic process

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7drj, PDBe:7drj, PDBj:7drj
• PDBsum: 7drj
• PubMed: 34901881
• UniProt: P63756|PGSA_STAAN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Gene Name=pgsA)