Structure of PDB 7d6x Chain B Binding Site BS02

Receptor Information

>7d6x Chain B (length=239) Species: 1772 (Mycolicibacterium smegmatis)

ATYDAKLRVWRGDDTGGELHDYTVEVNDGEVVLDIIHRLQATQTPDLAVR
WNCKAGKCGSCSAEINGRPRLMCMTRMSTFGEDEVVTVTPLRTFPVMRDL
VTDVSFNYEKARQIPSFTPPKDLQPGEYRMQQEDVNRSQEFRKCIECFLC
QNVCHVVRDHEENKENFAGPRFHMRIAELDMHPLDTVDRKEMAQDEFGLG
YCNITKCCTEVCPEHIKITDNALIPMKERVADRKYDPIV

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 7d6x Chain B Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7d6x Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster.
• Resolution: 2.88 Å
• Binding residue (original residue number in PDB): C145 I146 C148 F149 C151 C213 P214 I219
• Binding residue (residue number reindexed from 1): C144 I145 C147 F148 C150 C212 P213 I218
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0009060 aerobic respiration
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:7d6x, PDBe:7d6x, PDBj:7d6x
• PDBsum: 7d6x
• PubMed: 33876763
• UniProt: A0QPJ2