Structure of PDB 7c3s Chain B Binding Site BS02

Receptor Information
>7c3s Chain B (length=182) Species: 228410 (Nitrosomonas europaea ATCC 19718) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMNDALHIGLPPFLVQANNEPRVLAAPEARMGYVLELVRANIAADGGPFA
AAVFERDSGLLIAAGTNRVVPGRCSAAHAEILALSLAQAKLDTHDLSADG
LPACELVTSAEPCVMCFGAVIWSGVRSLVCAARSDDVEAIGFDDGPRPEN
WMGGLEARGITVTTGLLRDAACALLREYNACN
Ligand information
Ligand IDAZG
InChIInChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
InChIKeyLPXQRXLUHJKZIE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c12c(nc(nc1O)N)nn[nH]2
ACDLabs 10.04n1c(O)c2c(nc1N)nnn2
CACTVS 3.341Nc1nc(O)c2[nH]nnc2n1
FormulaC4 H4 N6 O
Name5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL;
8-AZAGUANINE
ChEMBLCHEMBL374107
DrugBankDB01667
ZINCZINC000096321491
PDB chain7c3s Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7c3s Structure guided mutagenesis reveals the substrate determinants of guanine deaminase.
Resolution1.66 Å
Binding residue
(original residue number in PDB)		F48 N66 H77
Binding residue
(residue number reindexed from 1)		F49 N67 H78
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047974 guanosine deaminase activity
Biological Process
GO:0006152 purine nucleoside catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7c3s, PDBe:7c3s, PDBj:7c3s
PDBsum7c3s
PubMed34010666
UniProtQ82Y41

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