Structure of PDB 7c3h Chain B Binding Site BS02

Receptor Information

>7c3h Chain B (length=505) Species: 5547 (Trichoderma viride)

ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHH
FTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLY
NNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDF
DKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFD
QAFSESVIDSFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVE
AISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHP
TQADAIRCLHYDNSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYP
SYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPEDELVELILQNLARLH
AEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPYLMRP
AAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRLLLER
WQYGL

Ligand information

• Ligand ID: LYS
• InChI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
• InChIKey: KDXKERNSBIXSRK-YFKPBYRVSA-O
• SMILES:
  CACTVS 3.341: N[CH](CCCC[NH3+])C(O)=O
  ACDLabs 10.04: O=C(O)C(N)CCCC[NH3+]
  OpenEye OEToolkits 1.5.0: C(CC[NH3+])C[C@@H](C(=O)O)N
  CACTVS 3.341: N[C@@H](CCCC[NH3+])C(O)=O
  OpenEye OEToolkits 1.5.0: C(CC[NH3+])CC(C(=O)O)N
• Formula: C6 H15 N2 O2
• Name: LYSINE
• PDB chain: 7c3h Chain B Residue 602

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7c3h Structural basis of strict substrate recognition of l-lysine alpha-oxidase from Trichoderma viride.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): R68 D212 F216 Y369 W371 A475 W476
• Binding residue (residue number reindexed from 1): R65 D209 F213 Y366 W368 A468 W469
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 1.4.3.14: L-lysine oxidase.

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:7c3h, PDBe:7c3h, PDBj:7c3h
• PDBsum: 7c3h
• PubMed: 32894626
• UniProt: A0A0G4DCU0