Structure of PDB 7bre Chain B Binding Site BS02

Receptor Information
>7bre Chain B (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEM
VIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARF
INHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDAKLP
CNCGAKRCRRFLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7bre Chain B Residue 2801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bre Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Resolution2.803 Å
Binding residue
(original residue number in PDB)		C2703 C2710
Binding residue
(residue number reindexed from 1)		C151 C158
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:7bre, PDBe:7bre, PDBj:7bre
PDBsum7bre
PubMed32697937
UniProtQ9UMN6|KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Gene Name=KMT2B)

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