Structure of PDB 7bbd Chain B Binding Site BS02

Receptor Information
>7bbd Chain B (length=160) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK
QLEDGRTLSDYNIQKESTLHLVLRLRAAMASAARLTMMWEEVTCPICLDP
FVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANM
VNNLKEISQE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7bbd Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7bbd RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		C107 H109 C127 C130
Binding residue
(residue number reindexed from 1)		C109 H111 C129 C132
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:7bbd, PDBe:7bbd, PDBj:7bbd
PDBsum7bbd
PubMed33619271
UniProtP0CG47|UBB_HUMAN Polyubiquitin-B (Gene Name=UBB);
P19474|RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (Gene Name=TRIM21)

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