Structure of PDB 7amv Chain B Binding Site BS02

Receptor Information
>7amv Chain B (length=1126) Species: 502057 (Vaccinia virus GLV-1h68) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLL
SFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVM
TKEGISITKISSYEGKDSHLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVF
INKQSVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRH
YKISLDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMP
PEVVYLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEF
KYEMLHNFLPHMNYTPDQLKGFYMISLLRKFLYCIFHTSRYPDRDSMVCH
RILTYGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGL
NHAFSSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPSVRKYHPSQ
YLYFCSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEKKICEYIRSY
YKDDISYFETGFPITIENALVASLNPNMICDFVTDFRRRKRMGFFGNLEV
GITLVRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPELESRLDDMTF
SDIQKEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQYDLCDFPAE
FRDGYVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRNKIDNGIHLM
YPERPIVISKALETSKIAANCFGQHVTIALMSYKGINQEDGIIIKKQFIQ
RGGLDIVTAKKHQVEIPLENFNNAYSKLESNGLVRLNAFLESGDAMARNI
SSSFDVSEKYTDMYKSRVERVQVELTDKVKVRVLTMKERRPILGDKFTTR
TSQKGTVAYVADETELPYDENGITPDVIINSTSIFSRKTISMLIEVILTA
AYSAKPYNNKGENRPVCFPSSNETSIDTYMQFAKQCYEHSNPKLSDEELS
DKIFCEKILYDPETDKPYASKVFFGPIYYLRLRHLTQDKATVRCRGKKTK
LIRQANEGRKRGGGIKFGEMERDCLIAHGAANTITEVLKDSEEDYQDVYV
CENCGDIAAQIKGINTCLRCSKLNLSPLLTKIDTTHVSKVFLTQMNARGV
KVKLDFERRPPSFYKPLDKVDLKPSF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7amv Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7amv Structural basis of the complete poxvirus transcription initiation process.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C1087 C1103 C1106
Binding residue
(residue number reindexed from 1)		C1051 C1067 C1070
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7amv, PDBe:7amv, PDBj:7amv
PDBsum7amv
PubMed34556871
UniProtQ49PH2

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