Structure of PDB 6zpl Chain B Binding Site BS02

Receptor Information
>6zpl Chain B (length=530) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPAFFM
ELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYY
FFSSMTHVLPWAYCNNPWNTHDCAGVLDHSLQRTSPSEEYWRLYVLKLSD
DIGNFGEVRLPLLGCLGVAWLVVFLCLIRGVVYFTATFPYVVLTILFVRG
VTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQAFYSLGCAWGGLITMAS
YNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD
HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAI
VDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASF
SLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAII
FFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLAR
TDGDTLLQRLKNATKPSRDWGPALLEHRTG
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain6zpl Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6zpl Structural insights into the inhibition of glycine reuptake.
Resolution3.945 Å
Binding residue
(original residue number in PDB)		G115 V118
Binding residue
(residue number reindexed from 1)		G9 V12
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6zpl, PDBe:6zpl, PDBj:6zpl
PDBsum6zpl
PubMed33658720
UniProtP48067|SC6A9_HUMAN Sodium- and chloride-dependent glycine transporter 1 (Gene Name=SLC6A9)

[Back to BioLiP]