Structure of PDB 6ymw Chain B Binding Site BS02

Receptor Information

>6ymw Chain B (length=340) Species: 559292 (Saccharomyces cerevisiae S288C)

SVPIPGIKDISKLKFFYGFKYLWNPTVYNKIFDKLDLTKTYKHPEELKVL
DLYPGVGIQSAIFYNKYCPRQYSLLEKRSSLYKFLNAKFEGSPLQILKRD
PYDWSTYSNLIDEERIFVPEVQSSDHINDKFLTVANVTGEGSEGLIMQWL
SCIGNKNWLYRFGKVKMLLWMPSTTARKLLARPGMHSRSKCSVVREAFTD
TKLIAISDANELKGFDSQCIEEWDPILFSAAEIWPTKGKPIALVEMDPID
FDFDVDNWDYVTRHLMILKRTPLNTVMDSLGHGGQQYFNSRITDKDLLKK
CPIDLTNDEFIYLTKLFMEWPFKPDILMDFVDMYQTEHSG

Ligand information

>6ymw Chain T (length=29)

cattatctaccgacaatatcaatacttat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ymw Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase.
• Resolution: 3.71 Å
• Binding residue (original residue number in PDB): R271 E338
• Binding residue (residue number reindexed from 1): R270 E337

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0008168 methyltransferase activity
• GO:0034246 mitochondrial transcription factor activity

Biological Process

• GO:0006390 mitochondrial transcription
• GO:0006391 transcription initiation at mitochondrial promoter
• GO:0032259 methylation
• GO:0032786 positive regulation of DNA-templated transcription, elongation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space
• GO:0005759 mitochondrial matrix
• GO:0034245 mitochondrial DNA-directed RNA polymerase complex

External links

• PDB: RCSB:6ymw, PDBe:6ymw, PDBj:6ymw
• PDBsum: 6ymw
• PubMed: 33278362
• UniProt: P14908|MTF1_YEAST Mitochondrial transcription factor 1 (Gene Name=MTF1)