Structure of PDB 6ydx Chain B Binding Site BS02

Receptor Information
>6ydx Chain B (length=853) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNII
LHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYT
LKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDE
PAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYL
VAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYF
EIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLV
TKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSY
EDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLM
LKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQDVKRMMKTW
TLQKGFPLVTVQKKGKELFIQQERFFLYLWHIPLSYVTEGRNYSKYQSVS
LLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYV
LSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQT
DLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSA
LLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDK
GWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQ
KLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTY
LFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLT
WWL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ydx Chain B Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ydx Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H464 H468 E487
Binding residue
(residue number reindexed from 1)		H306 H310 E329
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E431 H464 E465 H468 E487 E541 Y549
Catalytic site (residue number reindexed from 1) E273 H306 E307 H310 E329 E383 Y391
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ydx, PDBe:6ydx, PDBj:6ydx
PDBsum6ydx
PubMed32676150
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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