Structure of PDB 6y7f Chain B Binding Site BS02

Receptor Information
>6y7f Chain B (length=256) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YDNWIKDADPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRKPFE
LKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIVDYSRSPTALRM
ARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVK
FAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLV
QFVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTK
GQRLPK
Ligand information
Ligand ID37X
InChIInChI=1S/C27H52O12/c1-3-5-7-9-11-27(12-10-8-6-4-2,15-36-25-23(34)21(32)19(30)17(13-28)38-25)16-37-26-24(35)22(33)20(31)18(14-29)39-26/h17-26,28-35H,3-16H2,1-2H3/t17-,18-,19-,20-,21+,22+,23-,24-,25-,26-/m0/s1
InChIKeyTYXCLOLHZMMLEK-RNDJEAJNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.9.2CCCCCCC(CCCCCC)(COC1C(C(C(C(O1)CO)O)O)O)COC2C(C(C(C(O2)CO)O)O)O
ACDLabs 12.01O(CC(CCCCCC)(CCCCCC)COC1OC(CO)C(O)C(O)C1O)C2OC(C(O)C(O)C2O)CO
OpenEye OEToolkits 1.9.2CCCCCCC(CCCCCC)(CO[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)CO)O)O)O)CO[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)CO)O)O)O
CACTVS 3.385CCCCCCC(CCCCCC)(CO[CH]1O[CH](CO)[CH](O)[CH](O)[CH]1O)CO[CH]2O[CH](CO)[CH](O)[CH](O)[CH]2O
CACTVS 3.385CCCCCCC(CCCCCC)(CO[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O)CO[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O
FormulaC27 H52 O12
NameOctyl Glucose Neopentyl Glycol
ChEMBL
DrugBank
ZINCZINC000098208404
PDB chain6y7f Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6y7f Crystal structure of human ELOVL fatty acid elongase 7 (ELOVL7)
Resolution2.052 Å
Binding residue
(original residue number in PDB)		P23 E26 R106
Binding residue
(residue number reindexed from 1)		P10 E13 R93
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.199: very-long-chain 3-oxoacyl-CoA synthase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0009922 fatty acid elongase activity
GO:0016740 transferase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0030148 sphingolipid biosynthetic process
GO:0030497 fatty acid elongation
GO:0034625 fatty acid elongation, monounsaturated fatty acid
GO:0034626 fatty acid elongation, polyunsaturated fatty acid
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0042761 very long-chain fatty acid biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6y7f, PDBe:6y7f, PDBj:6y7f
PDBsum6y7f
PubMed
UniProtA1L3X0|ELOV7_HUMAN Very long chain fatty acid elongase 7 (Gene Name=ELOVL7)

[Back to BioLiP]