Structure of PDB 6xar Chain B Binding Site BS02

Receptor Information

>6xar Chain B (length=300) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSR
YEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNL
TKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVP
WKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPW
SSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLG
QWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTG

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6xar Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6xar SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function.
Resolution	2.501 Å
Binding residue (original residue number in PDB)	D229 T231 N233 Y235 E240
Binding residue (residue number reindexed from 1)	D178 T180 N182 Y184 E189
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0001784	phosphotyrosine residue binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0007166	cell surface receptor signaling pathway
GO:0023051	regulation of signaling

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Molecular Function

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Biological Process

External links

PDB	RCSB:6xar, PDBe:6xar, PDBj:6xar
PDBsum	6xar
PubMed	33617900
UniProt	P22681\|CBL_HUMAN E3 ubiquitin-protein ligase CBL (Gene Name=CBL)

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