Structure of PDB 6x5z Chain B Binding Site BS02

Receptor Information

>6x5z Chain B (length=369) Species: 9031 (Gallus gallus)

TALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVG
DEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLL
TEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDS
GDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAE
REIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERF
RCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTM
YPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQM
WITKQEYDEAGPSIVHRKC

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6x5z Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6x5z Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.
• Resolution: 4.24 Å
• Binding residue (original residue number in PDB): G13 G15 L16
• Binding residue (residue number reindexed from 1): G8 G10 L11
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0030240 skeletal muscle thin filament assembly
• GO:0048741 skeletal muscle fiber development

Cellular Component

• GO:0001725 stress fiber
• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005865 striated muscle thin filament
• GO:0005884 actin filament

External links

• PDB: RCSB:6x5z, PDBe:6x5z, PDBj:6x5z
• PDBsum: 6x5z
• PubMed: 32730789
• UniProt: P68139|ACTS_CHICK Actin, alpha skeletal muscle (Gene Name=ACTA1)