Structure of PDB 6x5r Chain B Binding Site BS02

Receptor Information
>6x5r Chain B (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLG
HHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKA
KKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWET
VFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPRPPYLPLA
VPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKH
PVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLA
TDDPSLLKEAKTKYPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFL
SQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQ
IAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYK
VREKIETVKYPTYPEAE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6x5r Chain B Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6x5r Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H389 H491
Binding residue
(residue number reindexed from 1)		H282 H384
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0017124 SH3 domain binding
GO:0046921 alpha-(1->6)-fucosyltransferase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006491 N-glycan processing
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0009312 oligosaccharide biosynthetic process
GO:0010468 regulation of gene expression
GO:0010761 fibroblast migration
GO:0016477 cell migration
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019082 viral protein processing
GO:0036071 N-glycan fucosylation
GO:0042355 L-fucose catabolic process
GO:0043112 receptor metabolic process
GO:0046368 GDP-L-fucose metabolic process
GO:1900407 regulation of cellular response to oxidative stress
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x5r, PDBe:6x5r, PDBj:6x5r
PDBsum6x5r
PubMed33004438
UniProtQ9BYC5|FUT8_HUMAN Alpha-(1,6)-fucosyltransferase (Gene Name=FUT8)

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