Structure of PDB 6w8v Chain B Binding Site BS02

Receptor Information
>6w8v Chain B (length=825) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGTYFFQLWYNQEYARFESPPKTQPTEDNKHK
FCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYL
PPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPEPY
RIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDINML
YWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSK
TKNFEDPPNHARSPGNKLPKLRTLDVFSGCGGLSEGFHQAGISETLWAIE
MWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVE
MLCGGPPCQGFSGMNRFNSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFV
SYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGE
KLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMS
DLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVA
ARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGAL
RGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFF
STTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNILDRH
RQVGNAVPPPLAKAIGLEIKLCLLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w8v DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context
Resolution3.12 Å
Binding residue
(original residue number in PDB)		S981 Y983 K985 G1226 P1227 P1228 C1229 Q1230 S1233 M1235 E1269 V1271 R1313 R1314 R1315 N1510 T1527 T1530 G1536 K1537
Binding residue
(residue number reindexed from 1)		S236 Y238 K240 G455 P456 P457 C458 Q459 S462 M464 E494 V496 R538 R539 R540 N735 T752 T755 G761 K762
Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C458 E494 R538 R540
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6w8v, PDBe:6w8v, PDBj:6w8v
PDBsum6w8v
PubMed
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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