Structure of PDB 6vrf Chain B Binding Site BS02

Receptor Information
>6vrf Chain B (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DILSVGILVKERWKVLRKIGGGEIYDALDMLTRENVALKVESAQQPKQVL
KMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRG
TFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYM
LDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWS
LFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDH
ISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6vrf Chain B Residue 307 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vrf Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		N146 D163
Binding residue
(residue number reindexed from 1)		N135 D152
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6vrf, PDBe:6vrf, PDBj:6vrf
PDBsum6vrf
PubMed32424773
UniProtQ6IQ55|TTBK2_HUMAN Tau-tubulin kinase 2 (Gene Name=TTBK2)

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