Structure of PDB 6voy Chain B Binding Site BS02

Receptor Information

>6voy Chain B (length=259) Species: 11927,273057

SPAELHSFTHCGQTALTLQGATTTEASNILRSCHACRGLLPNHIWQGDIT
HFKYKNTLYRLHVWVDTFSGAISATQKRKETSSEAISSLLQAIAYLGKPS
YINTDNGPAYISQDFLNMCTSLAIRHTTHVPYNPTSSGLVQRSNGILKTL
LYKYFTDKPDLPMDNALSIALWTINHLNVLTNCHKTRWQLHHSPRLQPIP
ETRSLSNKQTHWYYFKLPGLNSRQWKGPQEALQEAAGAALIPVSASSAQW
IPWRLLKRA

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6voy Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6voy Structural basis of host protein hijacking in human T-cell leukemia virus integration.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): H6 H10 C33 C36
• Binding residue (residue number reindexed from 1): H6 H10 C33 C36
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number:
  2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0004521 RNA endonuclease activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6voy, PDBe:6voy, PDBj:6voy
• PDBsum: 6voy
• PubMed: 32561747
• UniProt: P14078;
  P39476|DN7D_SACS2 DNA-binding protein 7d (Gene Name=sso7d)