Structure of PDB 6vff Chain B Binding Site BS02

Receptor Information
>6vff Chain B (length=436) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLA
KARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGK
FGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMS
DRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGF
RLKENVQFHLYISTSPCGDARIFSPHEARGQLRTKIESGQGTIPVRSLTM
SCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRI
SNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINA
TTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLA
AKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>6vff Chain D (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cguagcuaucagagccccccagcaucgcgagc
................................
Receptor-Ligand Complex Structure
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PDB6vff Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		M238 H259 K282 K594
Binding residue
(residue number reindexed from 1)		M4 H25 K48 K330
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:6vff, PDBe:6vff, PDBj:6vff
PDBsum6vff
PubMed32597966
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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