Structure of PDB 6v6q Chain B Binding Site BS02

Receptor Information
>6v6q Chain B (length=291) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV
KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLFVIVEF
ASKGNLREFLRARRPPGMEEEQMTFKDLVSCTFQLARGMEFLASQKCIHR
DLAARNVLVTENNVMKIADFGLARDINNIDYFKKTTNGRLPVKWMAPEAL
FDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP
ANCTNELFMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6v6q Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6v6q The combined action of the intracellular regions regulates FGFR2 kinase activity
Resolution2.46 Å
Binding residue
(original residue number in PDB)		N631 D644
Binding residue
(residue number reindexed from 1)		N156 D169
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D626 R630 N631 D644
Catalytic site (residue number reindexed from 1) D151 R155 N156 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6v6q, PDBe:6v6q, PDBj:6v6q
PDBsum6v6q
PubMed
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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