Structure of PDB 6ux2 Chain B Binding Site BS02

Receptor Information
>6ux2 Chain B (length=600) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNMKIIGRRIERIRNEHAETWFLDENHPYRTWAYHGSYEAPTQGSASSLV
NGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQRVFKEKVDTRVPDPQEGTR
QVMNIVSSWLWKELGKRKRPRVCTKEEFINKVRSGAIFEEEKEWKTAVEA
VNDPRFWALVDREREHHLRGECHSCVYNMMGKREKKGSRAIWYMWLGARF
LEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYILEEMNRAPGGKMYAD
DTAGWDTRISKFDLENEALITNQMEEGHRTLALAVIKYTYQNKVVKVLRP
AEGGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQ
DLWLLRKPEKVTRWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLN
DMGKVRKDTQEWKPSTGWSNWEEVPFCSHHFNKLYLKDGRSIVVPCRHQD
ELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSA
VPVDWVPTGRTTWSIHGKGEWMTTEDMLMVWNRVWIEENDHMEDKTPVTK
WTDIPYLGKREDLWCGSLIGHRPRTTWAENIKDTVNMVRRIIGEKYMDYL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ux2 Chain B Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ux2 Structural basis for STAT2 suppression by flavivirus NS5.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		H714 C730 C849
Binding residue
(residue number reindexed from 1)		H430 C446 C565
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6ux2, PDBe:6ux2, PDBj:6ux2
PDBsum6ux2
PubMed32778820
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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