Structure of PDB 6ujc Chain B Binding Site BS02

Receptor Information
>6ujc Chain B (length=359) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLV
DVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIH
PERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTP
EGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPN
DGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKD
LLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNI
TAICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKCDNYAIIKPIGFNET
AKIHIHRNC
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6ujc Chain B Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ujc Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Resolution3.56 Å
Binding residue
(original residue number in PDB)		S114 E212
Binding residue
(residue number reindexed from 1)		S53 E151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0046872 metal ion binding
GO:1990430 extracellular matrix protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001573 ganglioside metabolic process
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0045766 positive regulation of angiogenesis
GO:0051216 cartilage development
GO:0060022 hard palate development
GO:0060674 placenta blood vessel development
GO:0061520 Langerhans cell differentiation
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0034686 integrin alphav-beta8 complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ujc, PDBe:6ujc, PDBj:6ujc
PDBsum6ujc
PubMed31955848
UniProtP26012|ITB8_HUMAN Integrin beta-8 (Gene Name=ITGB8)

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