Structure of PDB 6uja Chain B Binding Site BS02

Receptor Information
>6uja Chain B (length=359) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLV
DVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIH
PERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTP
EGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPN
DGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWYKD
LLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNI
TAICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKCDNYAIIKPIGFNET
AKIHIHRNC
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6uja Chain B Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6uja Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		S114 S116 E212
Binding residue
(residue number reindexed from 1)		S53 S55 E151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0046872 metal ion binding
GO:1990430 extracellular matrix protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001573 ganglioside metabolic process
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0009615 response to virus
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0045766 positive regulation of angiogenesis
GO:0051216 cartilage development
GO:0060022 hard palate development
GO:0060674 placenta blood vessel development
GO:0061520 Langerhans cell differentiation
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0034686 integrin alphav-beta8 complex
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6uja, PDBe:6uja, PDBj:6uja
PDBsum6uja
PubMed31955848
UniProtP26012|ITB8_HUMAN Integrin beta-8 (Gene Name=ITGB8)

[Back to BioLiP]