Structure of PDB 6u6x Chain B Binding Site BS02
Receptor Information
>6u6x Chain B (length=383) Species:
9606
(Homo sapiens) [
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MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGLWPYKGRPENKSFLYEIVSNKRNGIDVAKWDYFARDCHHL
GIQNNFDYKRFIKFARVICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNI
IDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEIL
YSTDPKLKDAREILKQIEYRNLFKKIKREDYESLPKEVASAKPKVLEDFI
VDVINMLIRVYCKKVDRKSLYAARQYFVQWCAD
Ligand information
>6u6x Chain F (length=4) [
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cgcc
Receptor-Ligand Complex Structure
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PDB
6u6x
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Resolution
2.58 Å
Binding residue
(original residue number in PDB)
K116 V117 N119 H125 D137 Q142 R145
Binding residue
(residue number reindexed from 1)
K2 V3 N5 H11 D23 Q28 R31
Enzymatic activity
Enzyme Commision number
3.1.5.-
External links
PDB
RCSB:6u6x
,
PDBe:6u6x
,
PDBj:6u6x
PDBsum
6u6x
PubMed
33531504
UniProt
Q9Y3Z3
|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)
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