Structure of PDB 6tp5 Chain B Binding Site BS02

Receptor Information

>6tp5 Chain B (length=356) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECR
LIIHLAQMKGLQRSQILPTVSQLDLFRLLDQNRDGHLQLREVLAQTRLGN
GWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAES
SELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVR
YGEGGHYHAHVDSGPVYPETICSHTVPFETSCRYMTVLFYLNNVTGGGET
VFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYL
PDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMA
RLAREG

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

6tp5 Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6tp5 Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
Resolution	2.25 Å
Binding residue (original residue number in PDB)	H328 D330 H441
Binding residue (residue number reindexed from 1)	H210 D212 H316
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.29: hypoxia-inducible factor-proline dioxygenase.

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418	L-ascorbic acid binding

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Molecular Function

External links

PDB	RCSB:6tp5, PDBe:6tp5, PDBj:6tp5
PDBsum	6tp5
PubMed	33334883
UniProt	Q9NXG6\|P4HTM_HUMAN Transmembrane prolyl 4-hydroxylase (Gene Name=P4HTM)

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