Structure of PDB 6ted Chain B Binding Site BS02

Receptor Information
>6ted Chain B (length=1122) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPI
DLPPRYLLKFEQIYLSKPTHWEDGAPSPMMPNEARLRNLTYSAPLYVDIT
KTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPL
DPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSS
RPTSTIWVSMLARIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHI
IYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKY
AKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHY
GNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTR
IISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSP
IGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQP
SPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLR
KLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKR
HIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVA
YCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYIT
NFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGY
NQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQ
GMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLTKRDCSTFLRTSETG
IVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQE
DMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPF
NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLK
HMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQF
LRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMP
YACKLLFQELMSMSIAPRMMSV
Ligand information
>6ted Chain P (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaccggagagggaacccacu
.....................
Receptor-Ligand Complex Structure
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PDB6ted Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K934 K942 H1053 R1080
Binding residue
(residue number reindexed from 1)		K882 K890 H1001 R1028
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ted, PDBe:6ted, PDBj:6ted
PDBsum6ted
PubMed32541898
UniProtI3LGP4

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