Structure of PDB 6t0n Chain B Binding Site BS02

Receptor Information
>6t0n Chain B (length=749) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRMITQRTIGKK
RVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVELL
ARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITGDNTK
WNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRGYMFE
SKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLSPGMM
MGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGHFKED
IQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVANFSME
LPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKDYRYT
YRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNLHIPE
VCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPAHGPAKSLEYD
AVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYRRP
IGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALKRQG
Ligand information
Receptor-Ligand Complex Structure
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PDB6t0n A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		R126 Q127 R135 N136 M227 K229 D230 I241 T243 R249 R353 P651 N671 R672 S673 N676
Binding residue
(residue number reindexed from 1)		R126 Q127 R135 N136 M219 K221 D222 I233 T235 R241 R345 P643 N663 R664 S665 N668
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t0n, PDBe:6t0n, PDBj:6t0n
PDBsum6t0n
PubMed32304664
UniProtH6QM91

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