Structure of PDB 6rxp Chain B Binding Site BS02

Receptor Information
>6rxp Chain B (length=235) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPEDKCHCCQFPAPLRPHVVW
FGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL
NLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK
Ligand information
>6rxp Chain D (length=11) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KGGAKRHRKIL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxp Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		F60 C131 H147 V188 F190 G191 E192 M193 Y201 H218 V219 Y220 P221
Binding residue
(residue number reindexed from 1)		F21 C92 H108 V149 F151 G152 E153 M154 Y162 H179 V180 Y181 P182
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxp, PDBe:6rxp, PDBj:6rxp
PDBsum6rxp
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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