Structure of PDB 6rw4 Chain B Binding Site BS02

Receptor Information

>6rw4 Chain B (length=225) Species: 9606 (Homo sapiens)

EDSTDFNDKILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFM
EPYIFGSRLDHDIIDLEQTATHLQLALNFTAHMAYRKGIILFISRNRQFS
YLIENMARDCGEYAHTRYFRGGMLTNARLLFGPTVRLPDLIIFLHTLNNI
FEPHVAVRDAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRL
FQTAITRAKEKRQQVEALYRLQGQK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6rw4 Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rw4 Distinct pre-initiation steps in human mitochondrial translation.
• Resolution: 2.97 Å
• Binding residue (original residue number in PDB): H93 D224 D240 D241
• Binding residue (residue number reindexed from 1): H41 D172 D188 D189
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation
• GO:0061668 mitochondrial ribosome assembly

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6rw4, PDBe:6rw4, PDBj:6rw4
• PDBsum: 6rw4
• PubMed: 32522994
• UniProt: Q9Y399|RT02_HUMAN Small ribosomal subunit protein uS2m (Gene Name=MRPS2)