Structure of PDB 6rng Chain B Binding Site BS02

Receptor Information
>6rng Chain B (length=334) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKFADELIANAAYIGTPGKGILAADESTGTIGKRLASINVENVESNRRAL
RELLFTTPGALPCLSGVILFEETLYQKSSDGTPFVDMLKSAGVLPGIKVD
KGTVELAGTNGETTTQGLDGLGDRCKKYYEAGARFAKWRAVLKIGVNEPS
QLAIHENAYGLARYAVICQENGLVPIVEPEILVDGSHDIQKCAAVTERVL
AACYKALSDHHVLLEGTLLKPNMVTPGSESAKVAPEVIAEHTVRALQRTV
PAAVPAIVFLSGGQSEEEATRNLNAMNQLKTKKPWSLSFSFGRALQQSTL
KTWGGKEENVKKAQEAFLVRCKANSEATLGAYKG
Ligand information
Ligand IDPRO
InChIInChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKeyONIBWKKTOPOVIA-BYPYZUCNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C[C@H](NC1)C(=O)O
CACTVS 3.341OC(=O)[C@@H]1CCCN1
CACTVS 3.341OC(=O)[CH]1CCCN1
OpenEye OEToolkits 1.5.0C1CC(NC1)C(=O)O
ACDLabs 10.04O=C(O)C1NCCC1
FormulaC5 H9 N O2
NamePROLINE
ChEMBLCHEMBL54922
DrugBankDB00172
ZINCZINC000000895360
PDB chain6rng Chain B Residue 408 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6rng Dipeptide Gly-Pro binds to a glycolytic enzyme fructose bisphosphate aldolase
Resolution2.15 Å
Binding residue
(original residue number in PDB)		G267 R298
Binding residue
(residue number reindexed from 1)		G262 R293
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D30 K142 E183 E185 K225 S295
Catalytic site (residue number reindexed from 1) D25 K137 E178 E180 K220 S290
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016829 lyase activity
GO:1901149 salicylic acid binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0031930 mitochondria-nucleus signaling pathway
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009506 plasmodesma

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rng, PDBe:6rng, PDBj:6rng
PDBsum6rng
PubMed
UniProtQ9SJQ9|ALFC6_ARATH Fructose-bisphosphate aldolase 6, cytosolic (Gene Name=FBA6)

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