Structure of PDB 6rie Chain B Binding Site BS02

Receptor Information
>6rie Chain B (length=1129) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLL
SFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVM
TKEGISITKISSYEGLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVFINKQ
SVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRHYKIS
LDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMPPEVV
YLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEFKYEM
LHNFLPHMNYTPDQLKGFYMISLLRKFLYCIFHTSRYPDRDSMVCHRILT
YGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGLNHAF
SSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPSVRKYHPSQYLYF
CSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEKKICEYIRSYYKDD
ISYFETGFPITIENALVASLNPNMICDFVTDFRRRKRMGFFGNLEVGITL
VRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPELESRLDDMTFSDIQ
KEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQYDLCDFPAEFRDG
YVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRNKIDNGIHLMYPER
PIVISKALETSKIAANCFGQHVTIALMSYKGINQEDGIIIKKQFIQRGGL
DIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLVRLNAFLESGDAMA
RNISSSFDVSEKYTDMYKSRVERVQVELTDKVKVRVLTMKERRPILGDKF
TTRTSQKGTVAYVADETELPYDENGITPDVIINSTSIFSRKTISMLIEVI
LTAAYSAKPYNNKGENRPVCFPSSNETSIDTYMQFAKQCYEHSNPKLSDE
ELSDKIFCEKILYDPETDKPYASKVFFGPIYYLRLRHLTQDKATVRCRGK
KTKLIRQANEGRKRGGGIKFGEMERDCLIAHGAANTITEVLKDSEEDYQD
VYVCENCGDIAAQIKGINTCLRCSKLNLSPLLTKIDTTHVSKVFLTQMNA
RGVKVKLDFERRPPSFYKPLDKVDLKPSF
Ligand information
Receptor-Ligand Complex Structure
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PDB6rie Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K777 R1045 K1046 K1052 M1056
Binding residue
(residue number reindexed from 1)		K757 R1012 K1013 K1019 M1023
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rie, PDBe:6rie, PDBj:6rie
PDBsum6rie
PubMed31835031
UniProtQ76ZP7|RP132_VACCW DNA-directed RNA polymerase 133 kDa polypeptide (Gene Name=OPG151)

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