Structure of PDB 6ra4 Chain B Binding Site BS02

Receptor Information
>6ra4 Chain B (length=130) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPTAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEI
THCGQMKRKYRVCNVTRRPASHQTFPLQTVECTVAQYFKDRHKLVLRYPH
LPCLQVGQEQKHTYLPLEVCNIVAGQRCIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ra4 How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		F216 H263 M267 R269 Y271 R272 F286 Y303 R307 H308 K327 H328 T329 Y330 G341
Binding residue
(residue number reindexed from 1)		F5 H52 M56 R58 Y60 R61 F75 Y87 R91 H92 K111 H112 T113 Y114 G125
Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Gene Ontology

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Molecular Function
External links
PDB RCSB:6ra4, PDBe:6ra4, PDBj:6ra4
PDBsum6ra4
PubMed31021613
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

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