Structure of PDB 6r65 Chain B Binding Site BS02

Receptor Information
>6r65 Chain B (length=623) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETL
ENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDN
NDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTS
GIVIQVFPLHDSEALKKLEDTWYTKYQPIDSIRGYFGETIALYFGFLEYF
TFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANM
TYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVS
LPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAI
VIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFY
IAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQ
ALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLA
AAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVV
TNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPR
HIQMKLARLEFESLEALKQQQMK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6r65 Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r65 The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E448 D497 E500 E529 D533
Binding residue
(residue number reindexed from 1)		E430 D479 E482 E511 D515
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r65, PDBe:6r65, PDBj:6r65
PDBsum6r65
PubMed31477691
UniProtQ9NW15|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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