Structure of PDB 6qhd Chain B Binding Site BS02

Receptor Information
>6qhd Chain B (length=532) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGSV
TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKR
RQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKG
DPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQF
TTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMN
MEESNNGSLSAEFKHLTLREQRASLIVTEELHLITFETEVYHQGLKIDLE
THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVA
EVLSWQFSSTTKRGLSIEQLTTLAEKLLGPYSGCQITWAKFCKENMAGKG
FSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLL
RFSESSKEGGVTFTWVETQIQSVEPYTKQQLNNMSFAEIIMGYKIILVSP
LVYLYPDIPKEEAFGKYCRAPYLKTKFICVTP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6qhd Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		M331 H332 K340 V343 Q344 N466 I467
Binding residue
(residue number reindexed from 1)		M186 H187 K195 V198 Q199 N311 I312
Binding affinityPDBbind-CN: Kd=20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6qhd, PDBe:6qhd, PDBj:6qhd
PDBsum6qhd
PubMed31170499
UniProtP40763|STAT3_HUMAN Signal transducer and activator of transcription 3 (Gene Name=STAT3)

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