Structure of PDB 6qcw Chain B Binding Site BS02

Receptor Information
>6qcw Chain B (length=745) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGF
LIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIR
GFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGIS
MTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIA
RLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEE
GTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALF
VNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDG
FVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQL
FIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYN
LRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSEADITPAHGPVKKM
DYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASY
RKPVGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI
Ligand information
>6qcw Chain R (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uauaccucugcuucugcuauu
.....................
Receptor-Ligand Complex Structure
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PDB6qcw Structural snapshots of actively transcribing influenza polymerase.
Resolution2.88 Å
Binding residue
(original residue number in PDB)		G125 R126 Q127 N136 M227 K229 D230 A242 T243 R249 L271 P272 V273 G274 G352 K353 M412 N414 N670 R671 S672 N675
Binding residue
(residue number reindexed from 1)		G126 R127 Q128 N137 M228 K230 D231 A243 T244 R250 L272 P273 V274 G275 G353 K354 M413 N415 N666 R667 S668 N671
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qcw, PDBe:6qcw, PDBj:6qcw
PDBsum6qcw
PubMed31160782
UniProtQ5V8Y6

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