Structure of PDB 6o3f Chain B Binding Site BS02

Receptor Information
>6o3f Chain B (length=517) Species: 471473 (Chlamydia trachomatis L2b/UCH-1/proctitis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEYLQHEDYLYRTSKLKEIRDLGINPYPYQYTDCLEVQEIRNQFVDNELG
DSEAAFRKETPKVRFAGRLVLFRSMGKNAFGQILDNDAKIQVMFNRDFSA
VAGLAADAGISPIKFIEKKLDLGDILGLEGYLFFTHSGELTVLVETVTLL
CKSLISLPDKHAGLADKEIRYRKRWADLISSEDVRKTFLTRSRILKLIRE
YMDQQSFLEVETPILQTVYGGAEATPFVTTLQALHAEMFLRISLEIALKK
LLVGGMSRVYEIGKVFRNEGIDRTHNPEFTMIEAYAAYWDYNDVMKCVEN
LVEYIVRALNNGETQVQYSHLKSGPQVVDFKAPWIRMTMKESISVYGGVD
VDLHADHELRKILETQTSLPEKTYVHASRGELIALLFDELVCDKLIAPHH
ITDHPLETTPLCKTLRSGDETLVERFESFCLGKELCNAYSELNDPLQQRK
LLEEQMRKKALNPDSEYHPIDEEFLEALCQGMPPAGGFGIGIDRLVMMLT
DAASIRDVLFFPVMRRI
Ligand information
Ligand IDLYS
InChIInChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1
InChIKeyKDXKERNSBIXSRK-YFKPBYRVSA-O
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCCC[NH3+])C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCC[NH3+]
OpenEye OEToolkits 1.5.0C(CC[NH3+])C[C@@H](C(=O)O)N
CACTVS 3.341N[C@@H](CCCC[NH3+])C(O)=O
OpenEye OEToolkits 1.5.0C(CC[NH3+])CC(C(=O)O)N
FormulaC6 H15 N2 O2
NameLYSINE
ChEMBL
DrugBank
ZINC
PDB chain6o3f Chain B Residue 724 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6o3f Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and a difluoro cyclohexyl chromone ligand
Resolution2.4 Å
Binding residue
(original residue number in PDB)		G225 S247 E249 E287 Y289 N441 Y443 E445
Binding residue
(residue number reindexed from 1)		G221 S243 E245 E283 Y285 N437 Y439 E441
Annotation score5
Enzymatic activity
Enzyme Commision number 6.1.1.6: lysine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6o3f, PDBe:6o3f, PDBj:6o3f
PDBsum6o3f
PubMed
UniProtB0BAN6|SYK_CHLTB Lysine--tRNA ligase (Gene Name=lysS)

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